Download e-book for kindle: Advances in Clinical Child Psychology by John L. R. Rubenstein, Linda Lotspeich (auth.), Benjamin B.

By John L. R. Rubenstein, Linda Lotspeich (auth.), Benjamin B. Lahey, Alan E. Kazdin (eds.)

ISBN-10: 1461398355

ISBN-13: 9781461398356

ISBN-10: 1461398371

ISBN-13: 9781461398370

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Therefore, the pattern of cortical synapses depends in part on the environmental stimuli that the animal experiences. We will elaborate on this topic in more detail in the section on critical periods in development. A fundamental process seen in neurodevelopment is that axons in many parts of the nervous system initially make an overabundance of synapses. For instance, thalamic afferents carrying information from 22 JOHN L. R. RUBENSTEIN et al. both eyes form synapses diffusely in Layer 4 of the primary visual cortex.

No discussion of axon pathway guidance is complete without a description of the growth and tropic factors that are found in the nervous system. The best known and studied is the nerve growth factor (NGF) discovered in the 1950s by Levi-Montalcini, Cohen, and co-workers (for a review of this subject, see Barde, 1989; Purves & Lichtman, 1985). NGF appears to be required for the survival of sympathetic-chain and dorsal-root-ganglion neurons. There is also evidence that NGF serves an important role in the physiology of cholinergic neurons in the forebrain.

Each of these have uncovered pathological findings in subsets of autistic patients. 1. Genetics Genetic studies have included epidemiological and karyotypical analyses. Twin studies have shown an increased concordance for autism among monozygotic as compared to dizygotic twins. The concordance rate of autism for monozygotic twins ranges between 36% and 100%, and the concordance rate for dizygotic twins ranges between 0% and 36% (Folstein & Rutter, 1988; Rimland, 1964; Ritvo, Freeman, MasonBrothers, Mo, & Ritvo, 1985; Smalley, Asarnow, & Spence, 1988).

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Advances in Clinical Child Psychology by John L. R. Rubenstein, Linda Lotspeich (auth.), Benjamin B. Lahey, Alan E. Kazdin (eds.)

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