By Kursad Turksen (Author)
This complete assessment of our present figuring out of grownup stem telephone varieties and their law examines the derivation, characterization, and application of grownup stem cells present in skeletal muscle, dental pulp, prostate, kidney, the attention, internal ear, and different tissues. The authors pay specified recognition to grownup stem telephone plasticity and their software in basic tissue homeostasis, in addition to their functions in regenerative drugs.
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Extra info for Adult Stem Cells
In the normal seminiferous epithelium, the density of Apale and Adark spermatogonia is relatively high. Therefore, the clones are too close together to decide whether Apale and Adark spermatogonia consist of clones of 1 or 2n cells comparable to spermatogonia in nonprimate mammals. However, such a clonal arrangement could be observed for both Apale and Adark spermatogonia during repopulation after irradiation, when spermatogonial density is much lower (55). In that situation, singles, pairs, and chains of Apale and Adark spermatogonia can be observed in tubule whole mounts.
In rhesus monkeys, shortly after irradiation, it was found that the number of Apale spermatogonia decreased to a minimum at about d 9 after irradiation; there was no change in the number of Adark spermatogonia (57). This pattern can be explained by the different proliferative activity of these cells. Irradiation kills the cells when they divide; conse- Spermatogonial Stem Cells 29 quently, the proliferating Apale die, and the quiescent Adark survive. However, after longer intervals than 9 d, the Adark spermatogonia also decreased in number concomitant with a transient rise in the number of Apale.
1968). Evolution of gonocytes in the rat testis during late embryonic and early post-natal life. Arch Anat Histol Embryol 51, 341–354. 63. de Rooij, D. G. (1998). Stem cells in the testis. Int J Exp Pathol 79, 67–80. 64. Resnick, J. , Bixler, L. , and Donovan, P. J. (1992). Longterm proliferation of mouse primordial germ cells in culture. Nature 359, 550–551. 65. van Dissel-Emiliani, F. , Spek, E. , van der Donk, J. , and de Rooij, D. G. (1993). Survival and proliferation of rat gonocytes in vitro.
Adult Stem Cells by Kursad Turksen (Author)