By Amitava Dasgupta, Jorge L. Sepulveda
This functional, easy-to-use consultant addresses interference concerns in all laboratory assessments, together with sufferer epigenetics, means of specimen assortment, enzymes, biomarkers. Clinicians and laboratory scientists can hence depend on one reference which speaks to either their wishes of exact specimen research and optimum sufferer care.
Erroneous health center and pathology laboratory effects may be complicated and problematical, specially in acute care events. whereas a few elements developing interference, might be pointed out within the laboratory, detecting many others is usually depending on scientific info unavailable to the laboratory scientists or pathologists. as a result, clinicians needs to develop into knowledgeable in deciding on such faulty experiences, and dealing with pathologists and laboratory scientists that will comprehend the resource of such interferences, right the implications, after which come to a decision what plan of action needs to be for correct sufferer management.
• functional info for either clinicians and laboratory scientists, provided within the kind of tables and charts for simple reference
• specialize in diversity and assets of interferences instead of information of toxicologic mechanisms that are good lined in toxicology textbooks
• Covers interferences throughout endocrine, oncology, hematology, immunohistochemistry, immunology, serology, microbiology, and molecular testing
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Extra resources for Accurate Results in the Clinical Laboratory: A Guide to Error Detection and Correction
Acid citrate dextrose tubes 8. Glycolytic inhibitor tubes. Tubes with additives must be thoroughly mixed by gentle inversion as per manufacturer-recommended protocols. Erroneous test results may be obtained when the blood is not thoroughly mixed with the additive. A discard tube (plastic/no additive) is sometimes used to remove air and prime the tubing when a winged blood collection kit is used. Tubes for microbiological blood cultures are filled first to avoid bacterial contamination from epidermal flora.
Furthermore, coagulation may still occur postcentrifugation in serum samples. Therefore, another advantage of plasma is that analyte determinations can be achieved in whole blood prior to plasma separation provided that a suitable anticoagulant has been used. For example, an anticoagulated whole blood specimen may be used for point-of-care measurements followed by plasma separation, which would avoid the delay associated with obtaining an additional specimen for laboratory analysis. Reduction of in Vitro Hemolysis In addition to the time delay associated with blood clotting, there is an increased risk of lysis and consequent false increases in many intracellular analytes such as potassium, iron, and hemoglobin released from erythrocytes in serum specimens.
Louis: Mosby; 2004.  van der Velde M, Bakker SJ, de Jong PE, Gansevoort RT. Influence of age and measure of eGFR on the association between renal function and cardiovascular events. Clin J Am Soc Nephrol 2010;5(11):2053À9.  Veldhuis JD, Roelfsema F, Iranmanesh A, Carroll BJ, Keenan DM, Pincus SM. Basal, pulsatile, entropic (patterned), and spiky (staccato-like) properties of ACTH secretion: impact of age, gender, and body mass index. J Clin Endocrinol Metab 2009;94 (10):4045À52.  Matsumoto AM.
Accurate Results in the Clinical Laboratory: A Guide to Error Detection and Correction by Amitava Dasgupta, Jorge L. Sepulveda